| Studies on repairing of hemisected thoracic spinal cord of adult rats by using a chitosan tube filled with alginate fibers |
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| 作者姓名： | LI Xiaoguang YANG Zhaoyang YANG Yi |
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| 作者单位： | 1. Beijing Center for Neural Regeneration and Repairing, Capital University of Medical Sciences, Beijing 100054, China; 2. Department of Bioengineering, Beijing University of Aeronautics and Astronautics, Beijing 100083, China; 3. National Center of Biomedical Analysis, Beijing 100850, China |
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| 基金项目： | 国家自然科学基金;国家高技术研究发展计划(863计划) |
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| 摘 要： | A chitosan tube filled with alginate fibers was implanted into the injured spinal cord of a rat for repairing the damaged tissue. Twelve months after the operation, the morphological observation demonstrated that this chitosan tube could induce regeneration of myelinated and non-myelinated axons and blood vessels. The Basso-Beattie-Bresnahan (BBB) behavioral evaluation confirmed that the implants played a key role in the long-term restoration of rats motor functions. It is a promising start in the treatment of the patients with the injury of the spinal cord.
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| 关 键 词： | spinal cord injury regeneration function recovery chitosan alginate behavioral evaluation |
Studies on repairing of hemisected thoracic spinal cord of adult rats by using a chitosan tube filled with alginate fibers |
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| LI Xiaoguang,YANG Zhaoyang,YANG Yi.Studies on repairing of hemisected thoracic spinal cord of adult rats by using a chitosan tube filled with alginate fibers[J].Progress in Natural Science,2006,16(10):1051-1055. |
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| Authors: | LI Xiaoguang YANG Zhaoyang YANG Yi |
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| Institution: | 1. Beijing Center for Neural Regeneration and Repairing,Capital University of Medical Sciences,Beijing 100054,China;Department of Bioengineering,Beijing University of Aeronautics and Astronautics,Beijing 100083,China
2. National Center of Biomedical Analysis,Beijing 100850,China |
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| Abstract: | A chitosan tube filled with alginate fibers was implanted into the injured spinal cord of a rat for repairing the damaged tissue. Twelve months after the operation, the morphological observation demonstrated that this chitosan tube could induce regeneration of myelinated and non-myelinated axons and blood vessels. The Basso-Beattie-Bresnahan (BBB) behavioral evaluation confirmed that the implants played a key role in the long-term restoration of rats motor functions. It is a promising start in the treatment of the patients with the injury of the spinal cord. |
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| Keywords: | spinal cord injury regeneration function recovery chitosan alginate behavioral evaluation |
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