| 高选择性5HT3受体拮抗剂盐酸格拉司琼离子选择性电极的研制与含量测定 |
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| 引用本文： | 曲中堂,袁若,柴雅琴,叶光荣.高选择性5HT3受体拮抗剂盐酸格拉司琼离子选择性电极的研制与含量测定[J].重庆大学学报(自然科学版),2009,32(8):979-982. |
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| 作者姓名： | 曲中堂 袁若 柴雅琴 叶光荣 |
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| 作者单位： | 西南大学化学化工学院;重庆医药高等专科学校; |
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| 基金项目： | 国家自然科学基金资助项目(20675064);;重庆市自然科学基金资助项目(CSTC-2005BB4100) |
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| 摘 要： | 研制了盐酸格拉司琼离子选择性电极。利用正交设计法综合研究了活性物质的含量以及增塑剂等因素对PVC膜电极响应性能的影响。结果表明,以盐酸格拉司琼四苯硼钠离子缔合物(膜中含量为4.8%)为活性物质,邻苯二甲酸二辛酯为增塑剂制成的PVC膜电极的性能最佳。该电极在5.0×10-2~1.0×10-5 mol.L-1范围内呈现能斯特响应,斜率为58.7 mV/pc,检测下限为8.0×10-6 mol.L-1。该电极可直接用于盐酸格拉司琼片剂的含量测定,回收率为99%~102%,其结果与高效液相色谱法一致。
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| 关 键 词： | 盐酸格拉司琼 离子选择电极 药物分析 含量测定 |
Preparation and content determination of ion-selective electrode granisetron hydrochloride with high selective 5-HT_3 receptor antagonist |
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| QU Zhong-tang,YUAN Ruo,CHAI Ya-qin,YE Guang-rong.Preparation and content determination of ion-selective electrode granisetron hydrochloride with high selective 5-HT_3 receptor antagonist[J].Journal of Chongqing University(Natural Science Edition),2009,32(8):979-982. |
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| Authors: | QU Zhong-tang YUAN Ruo CHAI Ya-qin YE Guang-rong |
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| Institution: | 1.Institute of Analytical Science;College of Chemistry and Chemical Engineering;Southwest University;Chongqing 400715;P.R.China;2.Chongqing Medical and Pharmaceutical College;Chongqing 400030;P.R.China |
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| Abstract: | A granisetron hydrochloride selective electrode is prepared based on granisetron-tetraphenylboron as a carrier.Orthogonal methodology is adapted for studying the impacts of active substance content and Plasticizer on response performance of PVC Membrane Electrode.The option of Granisetron hydrochloride-Sodium Tetraphenylboron Ion-Association Compounds(4.8% in membrane) as active substance and Di-n-octyl phthalate(DOP) as Plasticizer is the best scheme.A fast near-Nernstian response is shown for granisetron ... |
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| Keywords: | granisetron hydrochloride ion selective electrodes pharmaceutical analysis content determination |
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