Distribution of sister chromatid exchanges in different types of chromatin in the X chromosome ofMicrotus cabrerae |
| |
Authors: | M Bullejos M Burgos R Jiménez A Sánchez R Díaz de la Guardia |
| |
Institution: | (1) Departamento de Genética, Facultad de Ciencias, Universidad de Granada, E-18071 Granada, (Spain) |
| |
Abstract: | We used the X chromosomes ofMicrotus cabrerae as a model to analyze the distribution of sister chromatid exchanges (SCEs) on different types of chromatin, because of the marked heterogeneity of the heterochromatin in the entire short arm and a portion of the long arm of this chromosome. Computer-simulated distributions, according to an algorithm that makes it possible to modify the distribution on the basis of any possible hypothesis, were compared with real distributions by log-linear models. We found that the frequency of SCEs in different types of heterochromatin was higher than that expected for a random distribution, and located an SCE hot-spot at the junction between euchromatin and heterochromatin. The possible relationship between the distribution of SCEs and base composition or chromatin accessibility are discussed. |
| |
Keywords: | Sister chromatid exchanges (SCEs) Microtus cabrerae X chromosome chromatin structure |
本文献已被 SpringerLink 等数据库收录! |