| 活性氧对人体中与衰老相关物质的影响 |
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| 引用本文： | 戴宇飞,林永齐.活性氧对人体中与衰老相关物质的影响[J].吉林大学学报(理学版),1997(2). |
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| 作者姓名： | 戴宇飞 林永齐 |
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| 作者单位： | 吉林大学分子生物学系!长春，130023，吉林大学分子生物学系!长春，130023 |
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| 基金项目： | 国家重点实验室开放实验室资助 |
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| 摘 要： | 研究了过硫酸按-TEMED体系产生的超氧负离子对健康人血液中几种生物活性物质的作用，结果表明，可以使细胞膜发生脂质过氧化作用，产生丙二醒（MDA），使生物膜造成损伤．同时使血液中超氧化物歧化酶（SOD）、过氧化氢酶（CAT）、谷胱甘肽过氧化物酶（GSH－PX）活性均有所降低．通过对CAT纯品的研究揭示出在血液中经SOD，的作用产生毒性更强的·OH，它是使生物膜破坏及各种酶活性降低的主要原因．
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| 关 键 词： | 活性氧 谷脱甘肽过氧化物酶 超氧化物歧化酶 过氧化氢酶 |
The Effect of Active Oxygen on the Substance Relative to Aging in Human Body |
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| Dai Yufei, Lin Yongqi.The Effect of Active Oxygen on the Substance Relative to Aging in Human Body[J].Journal of Jilin University: Sci Ed,1997(2). |
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| Authors: | Dai Yufei Lin Yongqi |
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| Abstract: | The effect of active oxygen radicals generated by ammonium persulfate-TEMED systems on several substances in healthy man's blood was investigated. The results showed that can make lipid peroxygenized ln cell membrane and MDA produced, then the biomembrane was in-jured- Meanwhile the activity of superoxide dismutase (SOD), cataase (CAT) glutathione peroxidase (GSH-PX) in the blood decreased. The study of prue CAT revealed that the produced the more toxic. OH througy its interaction with SOD, Fe2+ in blood- The existence of. OH is the main rea-son for the memberane injury and the declination of the enzyme activity. |
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| Keywords: | active oxygen radical glutathione reroxidase catalase superoxide dismutase |
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