Binding of antimalarial drugs to hemozoin fromPlasmodium berghei |
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| Authors: | A Jearnpipatkul P Govitrapong Y Yuthavong P Wilairat B Panijpan |
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| Institution: | (1) Department of Biochemistry, Faculty of Science, Mahidol University, Rama VI Road, 4 Bangkok, (Thailand) |
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| Abstract: | Summary Chloroquine, quinacrine and mefloquine bind toPlasmodium berghei hemozoin, hemin, heme, protoporphyrin IX and protease digested methemoglobin. This binding may be the basis for drug accumulation and action in the parasite.Acknowledgments. We thank the World Health Organization, the National Research Council of Thailand and Mahidol University for financial support. Dr Prapin Wilairat's suggestions are appreciated. |
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