| AIKs相关的色氨酸-苏氨酸激酶家族 |
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| 引用本文： | 郭蜀光,束峰珏.AIKs相关的色氨酸-苏氨酸激酶家族[J].河南大学学报(自然科学版),2005,35(1):65-68. |
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| 作者姓名： | 郭蜀光 束峰珏 |
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| 作者单位： | 河南大学,生命科学学院,河南,开封,475001;复旦大学,遗传工程国家重点实验室,上海,200433 |
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| 基金项目： | 复旦大学遗传工程国家重点实验室开放课题 |
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| 摘 要： | 综述AIKs相关激酶在不同物种中的分布，及其在染色体分离及胞质分裂过程中的关键作用。
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| 关 键 词： | AIKs 激酶 有丝分裂 纺锤体 癌细胞 |
| 文章编号： | 1003-4978(2005)01-0065-04 |
| 修稿时间： | 2004年9月15日 |
AIKs- Related to the Erine/Threonine Kinases |
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| GUO Shu-guang,SHU Feng-jue.AIKs- Related to the Erine/Threonine Kinases[J].Journal of Henan University(Natural Science),2005,35(1):65-68. |
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| Authors: | GUO Shu-guang SHU Feng-jue |
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| Institution: | GUO Shu-guang~ |
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| Abstract: | The Aurora/Ipl1p serine/threonine kinases are emerging as key regulators of mitosis and cytokinesis. The drosophila melanogaster aurora is the first to be isolated from a multicellular organism. Then, various related kinases have been found in mammalian cells, including humans. These kinases localize to the mitotic apparatus, such as centrosome, bipolar spindle, or midbody. They are required for many mitotic events. Three human homologues are overexpressed in many cancer cells. The most important is that overexpression of one of them transforms cells. This review discusses the functions of Aurora/Ipl1p kinase during mitosis and carcinogenesis. |
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| Keywords: | AIKs kinases mitosis bipolar spindle cancer cells |
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