9-Methyl-7-bromoeudistomin D,a potent inducer of calcium release from sarcoplasmic reticulum of skeletal muscle |
| |
| Authors: | J Kobayashi M Ishibashi U Nagai Y Ohizumi |
| |
| Institution: | (1) Mitsubishi Kasei Institute of Life Sciences, Minamiooya, Machida, 194 Tokyo, Japan |
| |
| Abstract: | Summary The Ca2+-releasing action of several derivatives of eudistomin D isolated from a marine tunicate was compared with that of caffeine. It was found that 9-methyl-7-bromoeudistomin D was approximately 1000 times more potent than caffeine in causing Ca2+ release from the sarcoplasmic reticulum.The authors thank Ms A. Muroyama of this institute for her technical assistance and Prof. K. L. Rinehart of University of Illinois for his encouragement. |
| |
| Keywords: | Eudistomin derivatives Ca2+ inducer \-carbolines sarcoplasmic reticulum structure-activity relationship |
| 本文献已被 SpringerLink 等数据库收录！ |
