| Chiral separation of racemic drugs using molecular imprinting |
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| 作者姓名： | LEI Jiandu TAN Tianwei |
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| 作者单位： | Department of Biochemical Engineering,School of Chemical Engineering, Beijing University of Chemical Technology, Beijing 100029, China,Department of Biochemical Engineering,School of Chemical Engineering, Beijing University of Chemical Technology, Beijing 100029, China |
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| 基金项目： | Supported by the National Natural Science Foundation of China (Grant Nos. 29976004 and 20136020) and Fok Yingtung Education Foundation (Grant No.71067) |
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| 摘 要： | Molecularly imprinted polymers (MIPs) of (S)-ketoprofen and (S)-naproxen are prepared using non-covalent imprinting in the presence of template molecules. The prepared MIPs are used as the chiral stationary phase to separate ramemic naproxen and ketoprofen. The results show that racemic naproxen and ketoprofen are efficiently resolved on MIPs. The effect of concentration of acetic acid in the mobile phase is studied, and the data are analyzed using the affinity chromatography model, and the close agreement is achieved between the simulated and experimental curves. The results suggest that the affinity chromatography mechanism controls the retention in this system. Moreover, the affinity chromatography equilibrium constants on (S)-naproxen and (S)-ketoprofen are estimated.
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| 关 键 词： | molecular imprinting polymer chiral separation naproxen affinity chromatography model |
Chiral separation of racemic drugs using molecular imprinting |
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| LEI Jiandu,TAN Tianwei.Chiral separation of racemic drugs using molecular imprinting[J].Progress in Natural Science,2002,12(12):900-903. |
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| Authors: | LEI Jiandu Tan Tianwei |
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| Institution: | Department of Biochemical Engineering,School of Chemical Engineering, Beijing University of Chemical Technology, Beijing 100029, China |
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| Abstract: | Molecularly imprinted polymers (MIPs) of (S)-ketoprofen and (S)-naproxen are prepared using non-covalent imprinting in the presence of template molecules. The prepared MIPs are used as the chiral stationary phase to separate ramemic naproxen and ketoprofen. The results show that racemic naproxen and ketoprofen are efficiently resolved on MIPs. The effect of concentration of acetic acid in the mobile phase is studied, and the data are analyzed using the affinity chromatography model, and the close agreement is achieved between the simulated and experimental curves. The results suggest that the affinity chromatography mechanism controls the retention in this system. Moreover, the affinity chromatography equilibrium constants on (S)-naproxen and (S)-ketoprofen are estimated. |
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| Keywords: | molecular imprinting polymer chiral separation naproxen affinity chromatography model |
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