Genetic and environmental influences on behavioral and neurochemical aspects of emotionality in rats |
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Authors: | C Gentsch M Lichtsteiner H Feer |
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Affiliation: | Psychiatrische Universit?tsklinik Basel, Biochem. Labor, Switzerland. |
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Abstract: | Three pairings of rats (two derived from divergent, selective breeding and one from divergent environmental conditions) were compared with regard to behavioral and hormonal parameters. Striking differences were observed: results obtained in our own laboratory as well as those found in a review of the literature pointed to higher emotionality (e.g., increased defecation and corticosterone secretion, etc.) in Roman low-avoidance, Wistar-Kyoto and group-housed rats, as compared to their respective counterparts, Roman high-avoidance, spontaneously hypertensive, and individually housed Wistar rats. Concomitant receptor binding studies reviewed here (3H-diazepam- and 3H-imipramine-binding sites) have revealed, however, less consistent intrapair differences. |
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