| 水解血清白蛋白对紫杉醇的化学修饰 |
| |
| 引用本文： | 邱晓航,周永洽.水解血清白蛋白对紫杉醇的化学修饰[J].南开大学学报,2000,33(1):58-60,75. |
| |
| 作者姓名： | 邱晓航 周永洽 |
| |
| 作者单位： | 南开大学化学系!天津，300071，南开大学化学系!天津，300071 |
| |
| 摘 要： | 紫杉醇对卵巢癌和乳腺癌有良好的疗效 ,但它不溶于水 ,使临床应用很不方便 .用水解的牛血清白蛋白修饰紫杉醇 ,可提高其水溶性
|
| 关 键 词： | 紫杉醇 水解 牛血清白蛋白 抗癌药 化学修饰 |
CHEMICAL MODIFICATION OF TAXOL WITH HYDROLYTIC BSA |
| |
| Qiu Xiaohang,Zhou Yongqia.CHEMICAL MODIFICATION OF TAXOL WITH HYDROLYTIC BSA[J].Acta Scientiarum Naturalium University Nankaiensis,2000,33(1):58-60,75. |
| |
| Authors: | Qiu Xiaohang Zhou Yongqia |
| |
| Abstract: | Taxol is a product isolated from the Pacitic yew tree and is a potent microtubulestablizing agent which has been approved for treatment of otherwise intractable ovarian cancer and beast cancer. Despite taxol's therapeutic promise, its aqueous insolubility hampers its clinical application. Here we report the modification of taxol with hydrolytic BSA which can improve taxol's solubility. |
| |
| Keywords: | taxol hydrolysis bovine serum albumin modification |
| 本文献已被 CNKI 维普 等数据库收录！ |
