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Protective effect of vitamins against trichothecene toxicity towardsSaccharomyces cerevisiae
Authors:B. Yagen  S. Halevy
Affiliation:(1) Department of Natural Products, Hebrew University, Pharmacy School, 91120 Jerusalem, (Israel);(2) Laboratory of Chemotherapy, Hebrew University, Pharmacy School, 91120 Jerusalem, (Israel)
Abstract:Summary Several trichothecene mycotoxins were shown to inhibit the growth ofSaccharomyces cerevisiae. This effect was most pronounced with the macrocyclic trichothecenes, especially verrucarin A. Much less growth inhibition was observed with T-2 toxin. Verrucarol, diacetoxyscirpenol, acetyl T-2 toxin, HT-2 toxin, T-2 tetraol and neosolaniol were inactive at a concentration of 75 mgrg of toxin per disc. Incubation ofS. cerevisiae with verrucarin A together with vitamins resulted in a decrease in toxicity. Pyridoxine-HCl, Ca-pantothenate, thiamine-HCl and agr-tocopheryl acetate were amongst the most potent of the vitamins tested which reversed growth inhibition, overcoming the inhibitory potential of the toxins.9 December 1986The authors thank Dr J. Behrend, Makor Company, Israel, for a generous gift of verrucarin A and roridin A.
Keywords:Saccharomyces cerevisiae  trichothecenes  mycotoxins  vitamins
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