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Reciprocal changes in serum free thyroxine fraction and thyrotropin level after administration of thiocyanate to rats
Authors:N. Michajlovskij  V. Štrbák  O. Földes
Affiliation:(1) Institute of Experimental Endocrinology of Slovak Academy of Sciences, 809 36 Bratislava, (Czechoslovakia)
Abstract:Summary The administration of thiocyanate to rats caused a significant increase of serum free thyroxine fraction, which coincided with the significant decrease of TSH level. The other components (AFT4, T4, T3) in serum at this time were decreased or unchanged. The finding suggests the role of free thyroxine fraction in feed-back regulation of TSH secretion.Acknowledgment. We thank Dr A. Parlow and the NIAMDD, Rat Pituitary Hormone Distribution Program, for material for rat TSH immunoassay; Dr J. Nauman (Inst. Postgrad. Med., Warsaw, Poland) for T3 antibody, and to Ing. J. Sadloncaron, Mrs M. Scaront'astná and Miss R Fajkoscaronová for technical assistance.
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