肾上腺糖皮质激素水平与肾病综合征相关性的临床研究

目的探讨肾上腺糖皮质激素水平与肾病综合征患者发病、预后的关系.方法采用放射免疫分析方法分组检测健康志愿者30例,肾病综合征患者组31例.结果两组血清皮质醇水平差异无统计学意义（P〉0.05）,但患有肾病综合征的血浆白蛋白降低程度极低的（〈20 g/L）患者其血清皮质醇水平偏低.经过激素治疗后,起效较慢,4～6周后24 ...

Clinical Study on the Correlation of Glucocorticoid Levels with Nephrotic Syndrome

Objective To clarity the relationship of glucocorticoid levels with the incidence and prognosis of patients with nephrotic syndrome.Method Radioimmunoassay method was used to group the objects,30 healthy volunteers and 31 patients with nephrotic syndrome.Results The serum cortisol levels in two group were not significantly different（P〉0.05）,but the serum cortisol levels of patients with nephrotic syndrome with very low plasma albumin levels（〈20 g / L） were lower.The onset of therapeutic effect of glucocoticoid therapy on nephritic syndrome was slower and the 24-hour urine protein levels started to decline on week 4-6 after the treatment.The recovery was negatively correlated with the patients ages,which meant the older the patients were,the slower the onsets of the therapeutic effects were.Conclusion The detection of glucocorticoid levels can help doctors determine early prognosis of nephrotic syndrome,and guide them to treat the patients with the hormone therapy.The patients with nephrotic syndrome with very low plasma serum should be given the therapy early enough,and an early treatment with immunosuppressive agents can be added earlier to reduce the urinary protein and relieve the syndrome as soon as possible if it was necessary.