Adipokinetic hormones: cell and molecular biology |
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Authors: | M. O'Shea R. C. Rayne |
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Affiliation: | (1) Sussex Centre for Neuroscience, School of Biological Sciences, University of Sussex, Falmer, BN1 9QG Brighton, Sussex, UK |
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Abstract: | Adipokinetic hormones AKH I (pGlu-Leu-Asn-Phe-Thr-Pro-Asn-Trp-Gly-Thr-NH2) and AKH II (pGlu-Leu-Asn-Phe-Ser-Trp-Gly-Thr-NH2) are synthesized by neurosecretory cells (NSC) of the corpora cardiaca (CC) in the locust,Schistocerca gregaria. These NSC constitute a homogeneous peptide factory as each cell synthesizes both AKH I and AKH II. This homogeneity makes the CC an excellent system in which to study aspects of neuropeptide biosynthesis. This report summarizes recent findings on AKH inactivation and metabolism, as well as on AKH prohormone processing and biosynthesis. |
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Keywords: | Corpus cardiacum neuropeptide adipokinetic hormone prohormone processing Schistocerca gregaria |
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