Glutathione peroxidase, superoxide dismutase and catalase in the red blood cells of GSH-normal and GSH-deficient sheep

Levels of glutathione peroxidase (GSH-Px), superoxide dismutase (SOD) and catalase were measured in the red blood cells of glutathione(GSH)-normal and GSH-deficient sheep. There were no significant differences in any of the 3 enzyme activities measured in the 2 groups of sheep. Also, there was no relationship between GSH level and the enzyme activity. These results suggest that inspite of large differences in GSH levels, the red blood cells from GSH-normal and GSH-deficient Merino sheep appear to have similar response to oxidative stress against which GSH is credited to play a major role.