|
|||||
|
|
MYH9 is associated with nondiabetic end-stage renal disease in African Americans |
|
| Authors: | Kao W H Linda Klag Michael J Meoni Lucy A Reich David Berthier-Schaad Yvette Li Man Coresh Josef Patterson Nick Tandon Arti Powe Neil R Fink Nancy E Sadler John H Weir Matthew R Abboud Hanna E Adler Sharon G Divers Jasmin Iyengar Sudha K Freedman Barry I Kimmel Paul L Knowler William C Kohn Orly F Kramp Kristopher Leehey David J Nicholas Susanne B Pahl Madeleine V Schelling Jeffrey R Sedor John R Thornley-Brown Denyse Winkler Cheryl A Smith Michael W Parekh Rulan S;Family Investigation of Nephropathy and Diabetes Research Group |
| Institution: | Department of Epidemiology, School of Medicine and Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland 21287, USA. wkao@jhsph.edu |
| Abstract: | As end-stage renal disease (ESRD) has a four times higher incidence in African Americans compared to European Americans, we hypothesized that susceptibility alleles for ESRD have a higher frequency in the West African than the European gene pool. We carried out a genome-wide admixture scan in 1,372 ESRD cases and 806 controls and found a highly significant association between excess African ancestry and nondiabetic ESRD (lod score = 5.70) but not diabetic ESRD (lod = 0.47) on chromosome 22q12. Each copy of the European ancestral allele conferred a relative risk of 0.50 (95% CI = 0.39-0.63) compared to African ancestry. Multiple common SNPs (allele frequencies ranging from 0.2 to 0.6) in the gene encoding nonmuscle myosin heavy chain type II isoform A (MYH9) were associated with two to four times greater risk of nondiabetic ESRD and accounted for a large proportion of the excess risk of ESRD observed in African compared to European Americans. |
| Keywords: | |
| 本文献已被 PubMed 等数据库收录！ | |