Green chemistry: C-C coupling and asymmetric reduction by innovative catalysis |
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| Authors: | Xiaofeng Wu Jun Mo Xiaohong Li Zeyn Hyder Jianliang Xiao |
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| Institution: | 1. Liverpool Centre for Materials and Catalysis, Department of Chemistry, University of Liverpool, Liverpool L69 7ZD, UK
2. Liverpool Centre for Materials and Catalysis, Department of Chemistry, University of Liverpool, Liverpool L69 7ZD, UK;Shanghai Key Laboratory of Green Chemistry and Chemical Processes, Department of Chemistry, East China Normal University, Shanghai 200062, China |
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| Abstract: | A catalytic method has been developed, which allows aryl halides to couple with various electron-rich olefins to give 1, 1'-substituted olefins. The palladium-catalysed coupling in ionic liquid solvent proceeds with high efficiency and remarkable regioselectivity without the need for any costly or toxic halide scavengers. Parallel to this, an environmentally-appealing method for the asymmetric reduction of ketones has been established, with which a variety of chiral alcohols can be accessed with high enantioselectivity in water with no need for any organic solvents. The same chemistry has been explored for the reduction of aldehydes, which is shown to be fast and highly chemoselective. These methods add new tools to the armoury of synthetic chemists. |
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| Keywords: | Heck reaction Transfer hydrogenation Ionic liquid Water Green chemistry |
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