Nuclear transport and the mitotic apparatus: an evolving relationship |
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Authors: | Richard Wozniak Brian Burke Valérie Doye |
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Institution: | 1. Department of Cell Biology, University of Alberta, Edmonton, AB, T6G 2H7, Canada 2. Institute of Medical Biology, 8A Biomedical Grove, #06-39 Immunos, Singapore, 138648, Singapore 3. Cell Biology Program, Institut Jacques Monod, UMR7592 CNRS/Université Paris Diderot, 15, rue Hélène Brion, 75205, Paris Cedex 13, France
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Abstract: | The trafficking of macromolecules between the cytoplasm and the nucleus is controlled by the nuclear pore complexes (NPCs)
and various transport factors that facilitate the movement of cargos through the NPCs and their accumulation in the target
compartment. While their functions in transport are well established, an ever-growing number of observations have also linked
components of the nuclear transport machinery to processes that control chromosome segregation during mitosis, including spindle
assembly, kinetochore function, and the spindle assembly checkpoint. In this review, we will discuss this evolving area of
study and emerging hypotheses that propose key roles for components of the nuclear transport apparatus in mitotic progression. |
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