Cellular communications in bone homeostasis and repair |
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Authors: | Ken-ichi Nakahama |
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Institution: | (1) Department of Cellular Physiological Chemistry, Graduate School, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8549, Japan |
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Abstract: | Cellular communication between the bone component cells osteoblasts, osteocytes and (pre-)osteoclasts is essential for bone
remodeling which maintains bone integrity. As in the remodeling of other organs, cell death is a trigger for remodeling of
bone. During the systematic process of bone remodeling, direct or indirect cell–cell communication is indispensable. Thus,
osteoblasts induce migration and differentiation of preosteoclasts, which is followed by bone resorption (by mature multinuclear
osteoclasts). After completion of bone resorption, apoptosis of mature osteoclasts and differentiation of osteoblasts are
initiated. At this time, the osteoblasts do not support osteoclast differentiation but do support bone formation. Finally,
osteoblasts differentiate to osteocytes in bone or to bone lining cells on bone surfaces. In this way, old bone areas are
regenerated as new bone. In this review the role of cell–cell communication in bone remodeling is discussed. |
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Keywords: | |
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