MEPE evolution in mammals reveals regions and residues of prime functional importance |
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Authors: | Claire Bardet Sidney Delgado Jean-Yves Sire |
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Institution: | 1. UMR 7138, Equipe “Evolution & Développement du Squelette” Université Paris 6, Paris, France 2. UMR 7138, Université Pierre et Marie Curie-Paris 6, Case 05, 7 Quai St-Bernard, 75005, Paris, France
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Abstract: | In mammals, the matrix extracellular phosphoglycoprotein (MEPE) is known to activate osteogenesis and mineralization via a
particular region called dentonin, and to inhibit mineralization via its ASARM (acidic serine-aspartate rich MEPE-associated
motif) peptide that also plays a role in phosphatemia regulation. In order to understand MEPE evolution in mammals, and particularly
that of its functional regions, we conducted an evolutionary analysis based on the study of selective pressures. Using 37
mammalian sequences we: (1) confirmed the presence of an additional coding exon in most placentals; (2) highlighted several
conserved residues and regions that could have important functions; (3) found that dentonin function was recruited in a placental
ancestor; and (4) revealed that ASARM function was present earlier, pushing the recruitment of MEPE deep into amniote origins.
Our data indicate that MEPE was involved in various functions (bone and eggshell mineralization) prior to acquiring those
currently known in placental mammals. |
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Keywords: | |
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