Lysozyme inhibitor conferring bacterial tolerance to invertebrate type lysozyme |
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Authors: | J M Van Herreweghe L Vanderkelen L Callewaert A Aertsen G Compernolle P J Declerck C W Michiels |
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Institution: | (1) Laboratory of Food Microbiology, Leuven Food Science and Nutrition Research Centre (LFoRCe), Katholieke Universiteit Leuven, Kasteelpark Arenberg 22, 3001 Leuven, Belgium;(2) Laboratory for Pharmaceutical Biology, Katholieke Universiteit Leuven, O&N II Herestraat 49, 3000 Leuven, Belgium; |
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Abstract: | Invertebrate (I-) type lysozymes, like all other known lysozymes, are dedicated to the hydrolysis of peptidoglycan, the major
bacterial cell wall polymer, thereby contributing to the innate immune system and/or digestive system of invertebrate organisms.
Bacteria on the other hand have developed several protective strategies against lysozymes, including the production of periplasmic
and/or membrane-bound lysozyme inhibitors. The latter have until now only been described for chicken (C-) type lysozymes.
We here report the discovery, purification, identification and characterization of the first bacterial specific I-type lysozyme
inhibitor from Aeromonas hydrophila, which we designate PliI (periplasmic lysozyme inhibitor of the I-type lysozyme). PliI has homologs in several proteobacterial genera and contributes to I-type lysozyme tolerance in A. hydrophila in the presence of an outer membrane permeabilizer. These and previous findings on C-type lysozyme inhibitors suggest that
bacterial lysozyme inhibitors may have an important function, for example, in bacteria-host interactions. |
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