Caveolin regulation of neuronal intracellular signaling |
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Authors: | Christopher M Stern Paul G Mermelstein |
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Institution: | (1) Department of Neuroscience, University of Minnesota, 6-145 Jackson Hall, 321 Church Street S.E., Minneapolis, MN 5455, USA; |
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Abstract: | Caveolin proteins physically interact with and compartmentalize membrane-localized signaling proteins to facilitate high-fidelity
intracellular signaling. Though primarily studied outside the nervous system, recent investigations have revealed that caveolin
proteins are key modulators of a variety of neuronal intracellular signaling pathways. Through both protein aggregation and
segregation, caveolin proteins can exert positive and negative influences on intracellular signaling. This review will detail
recent findings regarding caveolin function in the brain. |
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Keywords: | |
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