“Without Ub I am nothing”: NEMO as a multifunctional player in ubiquitin-mediated control of NF-κB activation |
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Authors: | Jérémie Gautheron Gilles Courtois |
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Institution: | 1. INSERM U781, Tour Lavoisier, H?pital Necker-Enfants Malades and Université Paris-Descartes, 149, rue de Sèvres, 75015, Paris, France
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Abstract: | Ubiquitination has emerged over the years as the most sophisticated way to modify proteins to affect their fate and function.
In particular, it has been reported to be instrumental in regulating several steps of the NF-κB signalling pathway which controls
inflammation, immunity, adhesion and cell survival. Integrating ubiquitination into NF-κB activation requires the regulatory
subunit of IKK, NEMO, which not only displays affinity for polyubiquitin chains, but is also posttranslationally modified
by a complex set of reactions involving ubiquitin. Here, we examine how studies of the NEMO/ubiquitin relationship have provided
novel insights into the IKK activation process and have uncovered molecular mechanisms that should represent in the future
attractive targets for specifically modulating NF-κB function. |
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Keywords: | |
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