An overview of RNAs with regulatory functions in gram-positive bacteria |
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Authors: | Pascale Romby Emmanuelle Charpentier |
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Institution: | 1. Architecture et Réactivité de l’ARN, Université de Strasbourg, CNRS, IBMC, 15 rue René Descartes, 67084, Strasbourg, France 2. Max F. Perutz Laboratories, University of Vienna, Dr. Bohrgasse 9, 1030, Vienna, Austria 3. The Laboratory for Molecular Infection Medicine Sweden (MIMS), Ume? University, 90187, Ume?, Sweden
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Abstract: | During the last decade, RNA molecules with regulatory functions on gene expression have benefited from a renewed interest.
In bacteria, recent high throughput computational and experimental approaches have led to the discovery that 10–20% of all
genes code for RNAs with critical regulatory roles in metabolic, physiological and pathogenic processes. The trans-acting RNAs comprise the noncoding RNAs, RNAs with a short open reading frame and antisense RNAs. Many of these RNAs act
through binding to their target mRNAs while others modulate protein activity or target DNA. The cis-acting RNAs include regulatory regions of mRNAs that can respond to various signals. These RNAs often provide the missing
link between sensing changing conditions in the environment and fine-tuning the subsequent biological responses. Information
on their various functions and modes of action has been well documented for gram-negative bacteria. Here, we summarize the
current knowledge of regulatory RNAs in gram-positive bacteria. |
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