DNA损伤下的P53基因调控网络建模与仿真

作为关键调控因子之一,P53在响应DNA损伤期间通过启动下游基因及其调控通路实现细胞周期捕获,促进病变细胞凋亡等系统功能。P53基因调控网络对于肿瘤形成与治疗研究都起到了积极的促进作用。旨在通过数学模型对单细胞内部响应外界干扰而产生的复杂调控机制进行研究,建立了DNA损伤下的P53基因调控网络动力学模型,利用微分方程方法分别实现了各子模块响应离子辐射的详细过程;通过Matlab7.0仿真平台实现了DNA损伤修复,ATM（ataxia telangiectasia mutated）激活以及P53-MDM2等模块间的动态调控过程;通过仿真结果简要分析了ATM激活时间阈值以及P53与MDM2（Mouse double minute two）基因响应离子辐射而产生的周期震荡等特性。

Modeling and Simulation of P53 Gene Regulatory Networks under DNA Damage

As a vital regulator,P53 plays an important role in the cell cycle arrest and the cell apoptosis by regulating downstream genes and their signal pathways in response to DNA damages.The significance of studies in P53 gene regulatory networks lies in the disclosing the complicated mechanisms of tumor forming and tumor therapy.To study the complicated regulations of the single cell in response to acute stresses from outside by mathematical model,a dynamic model of P53 gene regulatory networks under DNA damage was proposed.By using differential equations,the sub-modules were implemented in details,respectively.The processes of DNA generation and repair,ATM(ataxia telangiectasia mutated)activation and the dynamic regulations of P53-MDM2 feedback loop were proposed through the simulating platform in Matlab7.0.Meanwhile,the threshold of ATM activation and the oscillations between P53 and MDM2 in response to DNA damage were analyzed briefly.