Polyreactive antibodies in adaptive immune responses to viruses |
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Authors: | Email author" target="_blank">Hugo?MouquetEmail author Michel?C?Nussenzweig |
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Institution: | (1) Laboratory of Molecular Immunology, The Rockefeller University, 1230 York Avenue, New York City, NY 10021, USA;(2) Laboratory of Molecular Immunology, Howard Hughes Medical Institute, The Rockefeller University, 1230 York Avenue, New York City, NY 10021, USA |
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Abstract: | B cells express immunoglobulins on their surface where they serve as antigen receptors. When secreted as antibodies, the same
molecules are key elements of the humoral immune response against pathogens such as viruses. Although most antibodies are
restricted to binding a specific antigen, some are polyreactive and have the ability to bind to several different ligands,
usually with low affinity. Highly polyreactive antibodies are removed from the repertoire during B-cell development by physiologic
tolerance mechanisms including deletion and receptor editing. However, a low level of antibody polyreactivity is tolerated
and can confer additional binding properties to pathogen-specific antibodies. For example, high-affinity human antibodies
to HIV are frequently polyreactive. Here we review the evidence suggesting that in the case of some pathogens like HIV, polyreactivity
may confer a selective advantage to pathogen-specific antibodies. |
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Keywords: | |
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