A new approach to the prediction of transmembrane structures |
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Authors: | HongDe Liu Rui Wang XiaoQuan Lu Jing Chen Xiuhui Liu Lan Ding |
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Institution: | (1) College of Chemistry and Chemical Engineering, Northwest Normal University, Lanzhou, 730070, China;(2) College of Life Science, Northwest Normal University, Lanzhou, 730070, China |
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Abstract: | About 20%-30% of genome products have been predicted as membrane proteins, which have sig-nificant biological functions. The prediction of the amount and position for the transmembrane protein helical segments (TMHs) is the hot spot in bioinformatics. In this paper, a new approach, maximum spectrum of continuous wavelet transform (MSCWT), is proposed to predict TMHs. The predictions for eight SARS-CoV membrane proteins indicate that MSCWT has the same capacity with software TMpred. Moreover, the test on a dataset of 131 structure-known proteins with 548 TMHs shows that the predic-tion accuracy of MSCWT for TMHs is 91.6% and that for membrane protein is 89.3%. |
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Keywords: | maximum spectrum of continuous wavelet transform (MSCWT) membrane protein transmembrane protein helical segments (TMHs) |
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