| 缓释微球制剂的研究进展 |
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| 引用本文： | 李勋,韦祎,马光辉,胡琳琳.缓释微球制剂的研究进展[J].北京化工大学学报(自然科学版),2017,44(6):1-11. |
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| 作者姓名： | 李勋 韦祎 马光辉 胡琳琳 |
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| 作者单位： | 中国科学院过程工程研究所生化工程国家重点实验室,北京,100190;中国科学院过程工程研究所生化工程国家重点实验室,北京100190;江苏科技大学冶金与材料工程学院,江苏张家港215600 |
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| 基金项目： | 北京市科委生命科学领域前沿技术培育项目（Z141100000214007） |
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| 摘 要： | 由于具有广阔的应用前景和市场价值，近年来高分子微球作为新型的药物输送系统得到了广泛研究。本文从可生物降解微球材料的选择、制备方法以及质量评价的角度展开，综述了缓释微球制剂的研究应用进展。最后回顾了临床应用中的商品化缓释微球制剂应用现状，并对未来的发展方向提出了展望。
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| 关 键 词： | 缓释 微球 制备方法 质量评价 |
| 收稿时间： | 2017-06-30 |
Recent research and development prospects for sustained-release microspheres |
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| LI Xun,WEI Yi,MA GuangHui,HU LinLin.Recent research and development prospects for sustained-release microspheres[J].Journal of Beijing University of Chemical Technology,2017,44(6):1-11. |
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| Authors: | LI Xun WEI Yi MA GuangHui HU LinLin |
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| Institution: | 1. State Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing 100190;2. School of Metallurgy and Material Engineering, Jiangsu University of Science and Technology, Zhangjiagang, Jiangsu 215600, China |
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| Abstract: | Polymer microspheres can be used as a novel drug delivery system and have been extensively studied in the past few years due to their broad application and market value. In this paper, we review recent advances and new applications of these materials, with a main focus on the selection of the biodegradable material, preparation methods and quality evaluation. Furthermore, the current status of clinical applications of commercial microspheres is summarized concisely and their future development prospects are discussed. |
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| Keywords: | sustain-release microsphere preparation method quality evaluation |
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