| 蛋白质折叠的计算机模拟 |
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| 引用本文： | 解伟,王翼飞.蛋白质折叠的计算机模拟[J].上海大学学报(自然科学版),2000,6(2):145-149. |
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| 作者姓名： | 解伟 王翼飞 |
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| 作者单位： | 上海大学,理学院,上海,200436 |
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| 摘 要： | 介绍了计算机模拟蛋白质折叠问题的背景、模型和意义。在对模型问题采用Ｍｏｎｔｅ－Ｃａｒｌｏ方法和单纯遗传算法得到能量最小构象的基础上，提出了适用的混合遗传算法，并通过计算机模拟试验对三种方法作了比较。
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| 关 键 词： | 蛋白质折叠 遗传算法 二维晶格模型 计算机模拟 |
| 修稿时间： | : |
Computer Simulation for Protein Folding |
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| XIE Wei,WANG Yi fei.Computer Simulation for Protein Folding[J].Journal of Shanghai University(Natural Science),2000,6(2):145-149. |
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| Authors: | XIE Wei WANG Yi fei |
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| Abstract: | We mainly introduce the background,model and importance of computer simulation for protein folding. On the basis of getting the lowest energy conformation of the lattice model with Monte Carlo method and genetic algorithm, we present a hybrid genetic algorithm search procedure suitable for use in protein folding simulations. The three methods are compared with computer simulation test. The computing results indicate that the hybrid genetic algorithm is superior to conventional Monte Carlo and genetic algorithm for protein folding on two dimension lattice model. |
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| Keywords: | protein folding simulation hybrid genetic algorithm two dimension lattice model |
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