甲基杀虫脒盐酸盐对小白鼠繁殖力影响的初步试验

甲基杀虫脒盐酸盐34.62%原油,LD_(30)=313.74(雌)和273.10(雄)mg/kg]是毒性较低,对螟虫杀灭效高,但它对繁殖功能的影响少见报道。选用 NIH 小白鼠随机配组,开展高剂量(52.383与45.16ppm)、低剂量(10.45与9.1ppm)及对照组的繁殖试验,为期106天。第一次交配后,母鼠死亡率、受孕率、仔鼠出生存活率、哺育成活率,三组互相比较差异不显著(P>0.05)。第二次交配后,母鼠死亡率、受孕率及仔鼠哺育存活率,三组互相比较差异不显著(P>0.05),但仔鼠出生存活率差异非常显著(P<0.01)。全实验中母鼠体重增减率,三组相互比较差异不显著(P>0.05)。上述试验资料表明,甲基杀虫脒盐酸盐对 NIH 小白鼠的繁殖功能无明显影响。对于第二次交配所产仔鼠的出生存活率,三组互相比较有非常显著性差异,原因何在,有待深入研究。

A Preliminary Toxicological Study of the Chlordimeform Hydrochloride on the Reproductivity of Mice

Chlordimeform hydrochloride(CDH)is an insecticide used in rice planting area.It has relatively low toxity and high rate in killing the scirpophaga incerlulas larvae,but there were a few reports about its effect on their reproductive function.A preliminary toxicological study has been carried out on 100 NIH female and 50 male mice 8-12 gram in body weight,fed in fodder at libitum with high dose(52.28-45.51 ppm)and low dose(10.45-9.10ppm) of CDH and one control group.After the first copulation,the death rate and pregnancy rate of female,birth survival rate,and the breast-fed survival rate of new born mice showed no significant difference(P>0.05).After the second copulation,the death rate and pregnancy rate of female,and the breast fed survival rate of new born mice showed no significant difference (P>0.05).But the birth survival rate of the new born mice the experimental groups was much lower(P<0.01).During the whole test period, the difference of body weight increase of female mice among three groups were not remarkable(P>0.05).It can be seen that the effect of CDH on the reproductive function of NIH mice is not remarkable.But there is quite a difference in the birth survival rate of new born mice after the second copulation.The possible mechanism of this phenomenon has to be studied in future research.