Observations on salicyl hydroxamic acid,an experimental trypanocide |
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Authors: | A J Barnicoat W G van't Hoff P J Morrison H J Rogers |
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Institution: | (1) Department of Pharmacology and Clinical Pharmacology, Guy's Hospital Medical School, SE1 9RT London, (England) |
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Abstract: | Summary The inferior in vivo efficacy of salicyl hydroxamic acid against trypanosomiasis may be explained by its short half-life, high degree of protein binding and low tissue levels. |
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