Intravenous thyrotropin releasing hormone (TRH) enhances the excitatory actions of acetylcholine (ACh) on rat cortical neurons |
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Authors: | G G Yarbrough D K Singh |
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Institution: | (1) Merck Institute for Therapeutic Research, 19486 West Point, Pennsylvania, USA |
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Abstract: | Summary I. v. administered TRH (1.25-10 mg/kg) enhanced the excitatory actions of iontophoretically applied ACh on spontaneously active cerebral cortical neurons of pentobarbital-anaesthetized rats. These observations are consistent with the hypothesis of a cholinergic-link in the anti-anaesthetic actions of exogenously administered TRH. |
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