| 环丙沙星结晶热力学研究 |
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| 引用本文： | 刘勇,王静康,尹秋响. 环丙沙星结晶热力学研究[J]. 天津大学学报(自然科学与工程技术版), 2002, 35(3): 313-316 |
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| 作者姓名： | 刘勇 王静康 尹秋响 |
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| 作者单位： | 天津大学化工学院 天津300072(刘勇，王静康)，天津大学化工学院 天津300072(尹秋响) |
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| 基金项目： | 国家自然科学基金资助项目 (698740 0 4 ) |
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| 摘 要： | 测定了环丙沙星的熔化温度和熔化热，收集了不同配比的水／乙醇溶液中环丙沙星的溶解度数据，建立了环丙沙星在水／乙醇溶液中的溶解度模型，导出了环丙沙星活度系数与溶剂化常数的关系式，估算子环丙沙星的溶解热和溶剂化焓变，为环丙沙星的工业生产提供了热力学数据。
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| 关 键 词： | 环丙沙星 结晶 热力学 抗菌药物 |
| 文章编号： | 0493-2137(2001)04-0313-04 |
| 修稿时间： | 2001-12-04 |
Study on the Thermodynamics of Crystallizationof Ciprofloxacin Hydrochloride Mononydrate |
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| LIU Yong,WANG Jing kang,YIN Qiu xiang. Study on the Thermodynamics of Crystallizationof Ciprofloxacin Hydrochloride Mononydrate[J]. Journal of Tianjin University(Science and Technology), 2002, 35(3): 313-316 |
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| Authors: | LIU Yong WANG Jing kang YIN Qiu xiang |
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| Abstract: | The melting temperature,the melting heat and the solubility of ciprofloxacin hydrochloride monohydrate in water/ethanol solution are measured in this paper.The solubility model and the expression of the relationship between the activity coefficient and the solvation constant K of ciprofloxacin hydrochloride monohydrate have been established.The dissolution heat and the solvation energy of ciprofloxacin hydrochloride monohydrate in water/ethanol solution have been estimated using the experimental solubility data.This study aims at supplying valuable thermodynamics data for the industrial manufacture of ciprofloxacin hydrochloride monohydrate. |
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| Keywords: | ciprofloxacin hydrochloride monohydrate crystallization thermodynamics |
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