Histopathological modifications following immunotherapy with P 40 in rats bearing DMBA-induced mammary carcinoma |
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Authors: | K H Hollmann J M Verley |
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Institution: | (1) Service de Pathologie cellulaire et Cancérologie, Hôpital Marie Lannelongue, 133 avenue de la Résistance, F-92350 Le Plessis Robinson, (France) |
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Abstract: | Summary Female Sprague-Dawley rats bearing primarily-induced mammary carcinomas were treated with a new immunostimulating agent (P 40). The histopathological modifications encountered in tumors, lymph nodes, liver and spleen are described. Intratumoral injections provoke a more widespread response of the RES, and particularly a more intense reaction in the draining lymph nodes, than systemic treatment.This work was partly supported by a contract from CHU Necker Enfants Malades (Prof. J. Reynier), with the help of the Ligue Nationale Française contre le Cancer, the FEGE-FLUC and the International Society against Breast Cancer.We thank also the Ecole de Chirurgie, Paris, and the Pasteur Institute which kindly provided the immunostimulating agent P 40. The skillfull collaboration of Dr R. Villet, Mlle G. Amichot and Mme J. Garaudel is gratefully acknowledged. |
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