Chaperone-mediated autophagy: machinery,regulation and biological consequences |
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Authors: | Wenming?Li Qian?Yang Email author" target="_blank">Zixu?MaoEmail author |
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Institution: | (1) Departments of Pharmacology and Neurology, Emory University School of Medicine, Atlanta, GA 30322, USA; |
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Abstract: | Degradation of dysfunctional intracellular components in the lysosome system can occur through three different pathways, i.e.,
macroautophagy, microautophagy and chaperone-mediated autophagy (CMA). In this review, we focus on CMA, a type of autophagy
distinct from the other two autophagic pathways owing to its selectivity, saturability and competitivity by which a subset
of long-lived cytosolic soluble proteins are directly delivered into the lysosomal lumen via specific receptors. CMA participates
in quality control to maintain normal cell functions by clearing “old” proteins and provides energy to cells under nutritional
stress. Deregulation of CMA has recently been shown to underlie some diseases, especially neurodegenerative disorders for
which the decline with age in the activity of CMA may become a major aggravating factor. Therefore, targeting aberrant alteration
in CMA under pathological conditions could serve as a potential therapeutic strategy for treating related diseases. |
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Keywords: | |
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