Reversible depression of spontaneous brain electrical activity induced by actinomycin D and 7-aminoactinomycin D in rats |
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| Authors: | E Uezu Y Takada N Mishima |
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| Institution: | (1) Department of Physiology, Okayama University Medical School, 700 Okayama, Japan;(2) Department of Biological Science, Faculty of Pharmacology, Tokushima Bunri University, 770 Tokushima, Japan |
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| Abstract: | Summary Various types of actinomycin (C, D, S2, I and V) and 7-amino-analogue of actinomycin D were injected into the right lateral ventricle of the brain through a chronically implanted cannula. In rats but not in mice actinomycin D, actinomycin S2 and 7-aminoactinomycin D caused depression of EEG, while cardiac and respiratory activity were maintained. This effect of the EEG was reversible and a normal EEG pattern reappeared at least 3 h after administration. |
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