| 消旋托莫西汀的合成研究 |
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| 引用本文： | 李爱军,靳淑委,段 颖,张亚通. 消旋托莫西汀的合成研究[J]. 河北科技大学学报, 2008, 29(4): 328-331 |
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| 作者姓名： | 李爱军 靳淑委 段 颖 张亚通 |
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| 作者单位： | 河北科技大学化学与制药工程学院,河北石家庄,050018;河北科技大学理学院,河北石家庄,050018 |
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| 摘 要： | 对盐酸托莫西汀的关键中间体消旋托莫西汀的合成工艺进行了优化研究,设计了一条以3-甲氨基-1-苯基丙醇为原料,经过醚化反应、提纯、成盐的合成路线。在醚化反应中考察了原料物质的量比、反应温度、相转移催化剂对反应的影响,研究了提纯方式及成盐的影响,得到了最佳的反应条件。用3-甲氨基-1-苯基丙醇与邻氟甲苯在DMSO/KOH体系中进行醚化反应,成盐制得消旋托莫西汀,总收率为68.1%,纯度为99.5%。
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| 关 键 词： | 托莫西汀 抗抑郁药 合成 |
| 收稿时间： | 2008-09-01 |
| 修稿时间： | 2008-09-26 |
Study on synthesis of atomoxetine hydrochloride |
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| LI Ai-jun,JIN Shu-wei,DUAN Ying and ZHANG Ya-tong. Study on synthesis of atomoxetine hydrochloride[J]. Journal of Hebei University of Science and Technology, 2008, 29(4): 328-331 |
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| Authors: | LI Ai-jun JIN Shu-wei DUAN Ying ZHANG Ya-tong |
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| Affiliation: | LI Ai-jun1,JIN Shu-wei1,DUAN Ying2,ZHANG Ya-tong2(1.College of Chemical , Pharmaceutical Engineering,Hebei University of Science , Technology,Shijiazhuang Hebei 050018,China,2.College of Sciences,China) |
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| Abstract: | In this paper,we did a research on optimization for synthesis of racemic atomoxetine which is a very important intermediate for the synthesis of atomoxetine hydrochloride.It was synthesized using 3-methylamino-1-phenylpropanol as the starting material via such three steps as etherification,purification and salt formation.Optimum reaction conditions were obtained while the effects of raw materials molar ratio,reaction temperature and phase transfer catalyst on the reaction were studied in etherification,and ... |
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| Keywords: | atomoxetine antidepressants synthesis |
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