In vitro and in vivo studies on biodegradable magnesium alloy |
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| Authors: | Lida Hou Zhen Li Yu Pan LiDu Xinlin Li Yufeng Zheng and LiLi |
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| Institution: | Center for Biomedical Materials and Engineering, Harbin Engineering University, Harbin 150001, China;Center for Biomedical Materials and Engineering, Harbin Engineering University, Harbin 150002, China;Center for Biomedical Materials and Engineering, Harbin Engineering University, Harbin 150003, China;Center for Biomedical Materials and Engineering, Harbin Engineering University, Harbin 150004, China;Center for Biomedical Materials and Engineering, Harbin Engineering University, Harbin 150005, China;Center for Biomedical Materials and Engineering, Harbin Engineering University, Harbin 150006, China Department of Materials Science and Engineering, College of Engineering, Peking University, Beijing 100871, China;Center for Biomedical Materials and Engineering, Harbin Engineering University, Harbin 150007, China |
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| Abstract: | The microstructure, mechanical property, electrochemical behavior and biocompatibility of magnesium alloy (BioDe MSM?) were studied in the present work. The experimental results demonstrated that grain refining induced by extrusion improves the alloy strength significantly from 162 MPa for the as-cast alloy to 241 MPa for the as-extruded one. The anticorrosion properties of the as-extruded alloy also increased. Furthermore, the hemolysis ratio was decreased from 4.7% for the as-cast alloy to 2.9% for the as-extruded one, both below 5%. BioDe MSM? alloy shows good biocompatibility after being implanted into the dorsal muscle and the femoral shaft of the New Zealand rabbit, respectively, and there are no abnormalities after short-term implantation. In vivo observation indicated that the corrosion rate of this alloy varies with different implantation positions, with higher degradation rate in the femur than in the muscle. |
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| Keywords: | Magnesium alloy Extrusion Performance Biocompatibility |
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