Collagens in the developing and diseased nervous system |
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Authors: | T Hubert S Grimal P Carroll A Fichard-Carroll |
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Institution: | 1. INSERM U-583, Institut des Neurosciences de Montpellier, H?pital Saint-Eloi, 80 rue Augustin Fliche, 34 091, Montpellier Cedex 5, France 2. University Montpellier II, F34091, Montpellier, France
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Abstract: | Collagens are extracellular proteins characterized by a structure in triple helices. There are 28 collagen types which differ
in size, structure and function. Their architectural and functional roles in connective tissues have been widely assessed.
In the nervous system, collagens are rare in the vicinity of the neuronal soma, occupying mostly a “marginal” position, such
as the meninges, the basement membranes and the sensory end organs. In neural development, however, where various ECM molecules
are known to be determinant, recent studies indicate that collagens are no exception, participating in axonal guidance, synaptogenesis
and Schwann cell differentiation. Insights on collagens function in the brain have also been derived from neural pathophysiological
conditions. This review summarizes the significant advances which underscore the function and importance of collagens in the
nervous system.
Received 09 September 2008; received after revision 24 October 2008; accepted 28 October 2008 |
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Keywords: | " target="_blank"> Collagens neuron nervous system Knobloch syndrome Alzheimer disease axonal guidance neuromuscular junction Schwann cell differentiation |
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