| 软骨血管生成抑制因子抑制血管生成及其抗肿瘤作用的研究 |
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| 引用本文： | 沈先荣.软骨血管生成抑制因子抑制血管生成及其抗肿瘤作用的研究[J].复旦学报(自然科学版),1998,37(4):407-412. |
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| 作者姓名： | 沈先荣 |
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| 作者单位： | 复旦大学(沈先荣,吉冬梅,黄建生,刘为平,任大明,姚锡惠,龚叶芳),海军医学研究所(贾福星,王玲,雷呈祥,杨哓燕,孙加红) |
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| 摘 要： | 测定了小牛软骨血管生成抑制因子对血管内皮细胞细胞毒作用,对内皮细胞骨架系统及其运动迁移的抑制效应,对小鼠肿瘤生长的对抑制效应。
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| 关 键 词： | 软骨 血管生成 CAIF 抗肿瘤作用 肿瘤防治 |
The Effect of Cartilage Angiogenesis Inhibitory Factor on Angiogenesis and Tumor Growth |
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| Shen Xianrong, Ji Dongmei, Jia Fuxing, Huang Jiansheng,Liu Weiping, Ren Daming.The Effect of Cartilage Angiogenesis Inhibitory Factor on Angiogenesis and Tumor Growth[J].Journal of Fudan University(Natural Science),1998,37(4):407-412. |
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| Authors: | Shen Xianrong Ji Dongmei Jia Fuxing Huang Jiansheng Liu Weiping Ren Daming |
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| Abstract: | It was previously shown that cartilage angiogenesis inhibitory factor (CAIF) has an inhibitory effect on angiogenesis. The inhibitory effect of CAIF on the growth of bovine artery endothelial cells was studied using cytotoxity assay. The effect of CAIF on the skeleton of endothelial cells and Hela cells was investigated by whole cell scanning electron microscopy. The effect of CAIF on endothelial cell migration and the tumor growth were quantified by ordinary methods. The results showed that CAIF exerted inhibitory effects on the growth and migration of endothelial cells, and made the skeleton of endothelial cells wrinkled, but had no significant effect on that of Hela cells. CAIF also inhibited the tumor growth implanted on mice. These results suggest that CAIF is a specific angiogenesis inhibitory factor, and it inhibits the DNA synthesis and the skeleton of endothelial cells, so inhibits their growth and migration, then inhibits angiogenesis, "Tumor growth is angiogenesis dependent", CAIF inhibit. tumor growth significantly. |
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| Keywords: | cartilage angiogenesis endothelial cell cell skeleton cell migration carcinoma tumor therapy |
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