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| 对甲苯磺酸催化合成尼泊金乙酯 | |
| 引用本文： | 曹秀格,倪棠棣,刘筱虹,张保格,张江北.对甲苯磺酸催化合成尼泊金乙酯[J].河北科技大学学报,2000,21(2):70-72. |
| 作者姓名： | 曹秀格 倪棠棣 刘筱虹 张保格 张江北 |
| 作者单位： | 1. 河北科技大学化学与制药工程学院,河北石家庄,050018 2. 河北医科大学医化教研室,河北石家庄,050017 3. 河北石家庄市桥西区政府,河北石家庄,050051 4. 河北石家庄市油漆厂,河北石家庄,050051 |
| 摘 要： | 介绍了采用直接酯化法合成尼泊金乙酯的方法，以自制的对甲苯磺酸为催化剂，苯作共沸脱水剂，氧化铝为干燥剂。讨论了反应时间、原料物质的量配比，催化剂用量对收率的影响，确定了最佳工艺条件为ｎ（对羟基苯甲酸）：ｎ（乙醇）：ｎ（苯）：ｎ（对甲苯磺酸）＝１：４：１：０．１，反应时间８ｈ，温度７８～１１０℃，酯化反应产率高达８６．９％。 |
| 关 键 词： | 尼泊金乙酯 直接酯化法 乙醇 对甲苯磺酸 共沸脱水剂 催化剂 |
| 修稿时间： | 1999-11-09 |
Synthesis of Ethyl p-Hydroxyl Benzoate with p-Methyl-benzenesulfonic acid as Catalyst |
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| CAO Xiu-ge,NI Tang-di,LIU Xiao-hong,ZHANG Bao-ge,ZHANG Jiang-bei.Synthesis of Ethyl p-Hydroxyl Benzoate with p-Methyl-benzenesulfonic acid as Catalyst[J].Journal of Hebei University of Science and Technology,2000,21(2):70-72. | |
| Authors: | CAO Xiu-ge NI Tang-di LIU Xiao-hong ZHANG Bao-ge ZHANG Jiang-bei |
| Abstract: | The synthetic method with direct esterification for ethyl p-hydroxy-benzoate (nipagin B ) is described,p-methyl-benzenesulfonic acid is prepared by authors as catalyst, benene as the water-carrying agent, and aluminum oxide as the dryagent. The effects of reaction time,material ratio,amount of catalyst on yield are discused. Optimum process conditions are that p-hydroxybenzoc acid: ethanod: benzene: p methyl benzenesultfonic acid = 1: 4: 1: 1: 0.1, reaction time is 8h, temperature is 78~110℃,and the reaction yield can reach to 86. 9 %. |
| Keywords: | nipagin B direct esterification ethanol p-methyl-benzenesulfonic acid water-carrying agent catalyst |
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