| 纳米固体超强酸催化合成乙酰水杨酸(阿司匹林)冰片酯的研究 |
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| 引用本文： | 李敏,王倩,管月清,沈超,李丽莉. 纳米固体超强酸催化合成乙酰水杨酸(阿司匹林)冰片酯的研究[J]. 山东科技大学学报(自然科学版), 2008, 27(6) |
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| 作者姓名： | 李敏 王倩 管月清 沈超 李丽莉 |
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| 作者单位： | 1. 山东科技大学,化学与环境工程学院,山东,青岛,266510
2. 杭州师范大学,化学系,浙江,杭州,360016 |
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| 基金项目： | 山东省教育厅科技计划项目 |
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| 摘 要： | 以冰片、乙酰水杨酸为原料,首次采用纳米固体超强酸S2O82-/ZrO2催化合成了一种具有潜在生理活性的乙酰水杨酸冰片酯,该酯经1H NMR,13C NMR和IR进行了结构表征.通过考察催化剂用量,反应温度对酯化反应的影响以及产物重结晶溶剂的选择,发现当催化剂用量为0 3g,即冰片质量的6%,反应温度为110℃时,酯化率最高;无水乙醇为溶剂时,可以高回收率地得到纯净的目标产物.
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| 关 键 词： | 纳米固体超强酸 阿司匹林 冰片酯 催化合成 |
Study on the Synthesis of Aspirin Borneol Ester Catalyzed by Nanometer Solid Superacid S_2O_8~(2-)/ZrO_2 |
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| LI Min,WANG Qian,GUAN Yue-qing,SHEN Chao,LI Li-li. Study on the Synthesis of Aspirin Borneol Ester Catalyzed by Nanometer Solid Superacid S_2O_8~(2-)/ZrO_2[J]. Journal of Shandong Univ of Sci and Technol: Nat Sci, 2008, 27(6) |
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| Authors: | LI Min WANG Qian GUAN Yue-qing SHEN Chao LI Li-li |
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| Affiliation: | LI Min1,WANG Qian1,GUAN Yue-qing1,SHEN Chao2,LI Li-li1(1.College of Chemical , Environmental Eng.,SUST,Qingdao,Sh,ong 266510,China,2.Dept.of Chemistry,Hangzhou Normal University,Hangzhou,Zhejiang 310036,China) |
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| Abstract: | The aspirin borneol ester with biological activity has been synthesized by using the D-glucose as the starting material and the nanometer solid superacid S2O82-/ZrO2 as the catalyst for the first time.The products were characterized by IR,1H NMR and 13C NMR spectra.By examining the amount of catalyst,the impact of reaction temperature on esterification reaction and the choice of re-crystallization of the solvent,it finds out that when the amount of catalyst is 0.3g,that is,6% of borneol quality and the reac... |
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| Keywords: | nanometer solid superacidity aspirin borneol ester catalyzed synthesis |
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