The effects of acute and chronic morphine on regional distribution of cardiac output in brain |
| |
Authors: | W R Law R F Ritzmann J M Lee M A Kapin J L Ferguson |
| |
Institution: | (1) Alcohol and Drug Abuse Research and Training Program, Department of Physiology and Biophysics, University of Illinois at Chicago, Health Sciences Center, 60612 Chicago, Illinois, USA |
| |
Abstract: | Summary Both acute and chronic administration of morphine resulted in an increase in the percent cardiac output received by brain. However, various brain regions were affected differently by the drug treatments. The greatest increases in percent cardiac output received after chronic administration of morphine occurred in pons and cerebellum, while the greatest increases after acute administration occurred in cortex and midbrain. The changes found are in contrast with earlier studies which suggest that morphine has no effect on cerebral blood flow. |
| |
Keywords: | Guinea pig brain cardiac output morphine cerebral blood flow |
本文献已被 SpringerLink 等数据库收录! |