Selective antagonism by Mg2+ of amino acid-induced depolarization of spinal neurones |
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Authors: | R H Evans A A Francis J C Watkins |
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Institution: | (1) Department of Pharmacology, The Medical School, University Walk, BS8 1TD Bristol, (England) |
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Abstract: | Summary In the isolated frog or rat spinal cord, low concentrations of Mg2+ (0.5–1.00 mM) markedly depress, in a substantially Ca2+-independent manner, ventral root depolarizations produced by dorsal root stimulation and by certain amino acids (e. g. N-methyl-D-aspartate and L-homocysteate) but do not depress depolarizations produced by other excitatory amino acids (e. g. kainate and quisqualate). L-Aspartate-induced depolarizations are more sensitive to Mg2+ then are L-glutamate-induced depolarizations.Acknowledgment. We thank D. J. Oakes for skilled technica assistance. This work was supported by the Medical Research Council. |
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