Ethanol metabolism inDrosophila melanogaster |
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Authors: | M. C. Deltombe-Lietaert J. Delcour N. Lenelle-Monfort A. Elens |
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Affiliation: | (1) Unité de Génétique et Physiologie Cellulaire, Facultés N.D. de la Paix, 61, rue de Bruxelles, B-5000 Namur, (Belgium) |
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Abstract: | Summary A quantitative study of the transformation of ethanol into acetaldehyde shows that, inDrosophila melanogaster, the mitochondrial ethanol oxidizing system is not very active but that the part played by catalase appears more important than expected. For a strain without alcoholdehydrogenase, ethanol is highly toxic. The presence of acetaldehyde in the culture medium is toxic for all the strains studied. But, since even a strain without any aldehydeoxidase lives normally, the metabolic production of acetaldehyde does not seem dangerous. |
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