Enantiomeric cannabinoids: stereospecificity of psychotropic activity |
| |
| Authors: | R Mechoulam J J Feigenbaum N Lander M Segal T U J?rbe A J Hiltunen P Consroe |
| |
| Institution: | Brettler Medical Research Center, Faculty of Medicine, Hebrew University, Jerusalem, Israel. |
| |
| Abstract: | The 1,1-dimethylheptyl homolog of (-)-(3R,4R)-7-hydroxy-delta-6- tetrahydrocannabinol (compound II) is highly psychotropic in mice, rats and pigeons. The (+)-(3S,4S) enantiomer (III) was found to be psychotropically inactive at doses up to several thousand times those of the ED50 of (II). |
| |
| Keywords: | |
|
|
