Synthesis and Characterization of Magnetic SiO_2 Nanoparticles Loaded with Naproxen for Anti-inflammatory Therapy |
| |
| Authors: | YANG Xiao-Xia CHEN Zhi-long HUANG Peng ZHOU Xing-ping |
| |
| Affiliation: | 1. Key Laboratory of Textile Science & Technology of Eco-Textile,Ministry of Education,Donghua University,Shanghai 201620,China;College of Chemistry,Chemical Engineering and Biotechnology,Donghua University,Shanghai 201620,China
2. Key Laboratory of Textile Science & Technology of Eco-Textile,Ministry of Education,Donghua University,Shanghai 201620,China |
| |
| Abstract: | The aim of this study is to synthesize of magnetic SiO2 nanoparticles(MSNPs)loaded with Naproxen(NAPMSNPs)for targeting anti-flammatory therapy.The Fe3O4 nanoparticles were coated with a thin layer of silica by st(o)ber method and the drug was encapsulated in it simultaneously.The optimal conditions were investigated for the synthesis of MSNPs.The shape,size,and phase structure of NAP-MSNP were characterized by transmission electron micrographs(TEM)and X-ray diffraction(XRD).The drug encapsulation efficiency was confirmed by FT-IR and measured by UV spectrometry.The NAP-MSNPs show the response at the external magnetic field and the drug could be released readily from NAP-MSNPs.All of these facts suggest the NAP-MSNPs could be applied in a promising drug release-controlling system for targeting anti-inflammatory therapy. |
| |
| Keywords: | magnetic Naproxen nanoparticle drug delivery Fe3O4 |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
|
