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| 大鼠急性脑缺血及再灌注时白细胞介素(IL-6、IL-8)的变化及意义 | |
| 引用本文： | 钟德桥,李少华,高观月,梅兴国.大鼠急性脑缺血及再灌注时白细胞介素(IL-6、IL-8)的变化及意义[J].江汉大学学报(自然科学版),2002,30(2):11-12. |
| 作者姓名： | 钟德桥 李少华 高观月 梅兴国 |
| 作者单位： | 1. 江汉大学,医学与生命科学学院生物化学教础室,湖北,武汉,430056 2. 江汉大学,医学与生命科学学院解剖学教础室,湖北,武汉,430056 3. 华中科技大学,生命科学与技术学院,湖北,武汉,430076 |
| 摘 要： | 目的 :探讨大鼠急性脑缺血及再灌注后白细胞介素 (IL - 6、IL - 8)含量的变化。方法 :制备大鼠急性脑缺血及再灌注模型 ,采用酶联免疫吸附 (ELISA)法检测血清IL - 6、IL - 8含量。结果 :在脑缺血及再灌注过程中 ,IL - 6、IL - 8水平显著高于对照组 (P <0 .0 1) ,并且IL - 6水平有着逐步升高的现象 ,而IL -8在脑缺血后 2 0min及再灌注 1h后其含量呈持续性显著增高 (P <0 .0 1) ;再灌注 1～ 48h内虽有所降低 ,但仍维持在一个相当高的水平。结论 :IL - 6、IL - 8参与了脑缺血再灌注的损伤过程 |
| 关 键 词： | 脑缺血 再灌注 IL-6 IL-8 |
| 文章编号： | 1009-1777(2002)02-0011-02 |
| 修稿时间： | 2002年1月10日 |
Change and Meaning of Interleuking(IL-6、IL-8) During the Acute Cerebral Ischemin and reperfusion of Rats |
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| ZHONG De-qiao,LI Shao-hua,GAO Guan-yue,et al..Change and Meaning of Interleuking(IL-6、IL-8) During the Acute Cerebral Ischemin and reperfusion of Rats[J].Journal of Jianghan University:Natural Sciences,2002,30(2):11-12. | |
| Authors: | ZHONG De-qiao LI Shao-hua GAO Guan-yue |
| Abstract: | Objective: To study the change of interleuking(IL-6?IL-8)during the acute cerebral ischemin and reperfusion of rats. Methods: Acute cerebral ischemin and reperfusion rat model was established. By using ELISA,the levels of IL-6?IL-8 in serum were measured. Result:The serum levels of IL-6?IL-8 were significantly higher than those in normal controls(P< 0.01). Levels of IL-6 increased gradaully,levels of IL-8 decreased during 1～48 hours,but still maintained a very higher level. Conclousion:IL-6 and IL-8 is involved in the pathogenesis of cerebral ischemia and reperfusion. |
| Keywords: | cerebral ischemia reperfusion interleuking-6 interleuking-8 |
| 本文献已被 CNKI 万方数据 等数据库收录！ | |