| 转WMV-2CP基因甜瓜饲喂小鼠的安全性研究 |
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| 引用本文： | 应奇才,徐祥彬,薛大伟,潘慧娟,王慧中.转WMV-2CP基因甜瓜饲喂小鼠的安全性研究[J].杭州师范大学学报(自然科学版),2011(5):422-428. |
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| 作者姓名： | 应奇才 徐祥彬 薛大伟 潘慧娟 王慧中 |
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| 作者单位： | 杭州师范大学生命与环境科学学院; |
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| 基金项目： | 浙江省自然科学基金项目(393105); 钱江人才计划资助项目 |
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| 摘 要： | 转WMV-2CP基因甜瓜的小鼠急性和亚急性毒性试验、致突变试验以及30 d喂养安全性分析试验.其小鼠经口急性毒性半致死量LD50＞90 g/kg体重试验,表明该转基因食品属实际无急性毒性物质；微核实验和精子畸变实验及Ames实验均未发现有致突变作用；30 d喂养试验,54、108、162 g/kg体重各剂量组小鼠发育、...
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| 关 键 词： | 转基因甜瓜 WMV-2 CP基因 毒性试验 致突变试验 喂养实验 |
Safety Assessment of Transgenic Cucumis Melo with WMV-2CP Gene |
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| Authors: | YING Qi-cai XUE Da-wei XU Xiang-bin PAN Hui-juan WANG Hui-zhong |
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| Institution: | YING Qi-cai,XUE Da-wei,XU Xiang-bin,PAN Hui-juan,WANG Hui-zhong(College of Life and Environment Sciences,Hangzhou Normal University,Hangzhou 310036,China) |
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| Abstract: | Safety assessment of virus-resistant transgenic Cucumis melo was carried out.Toxicity experiments,mutation experiments,and 30-d feeding test were conducted on mice with transgenic Cucumis melo bearing WMV-2CP gene.The results show that oral LD50 for mice is larger than 90 g/kg so that the transgenic Cucumis melo belongs to nontoxic food.No mutation is found in micronucleus test,spermium aberration test or Ames test.The mice groups with 54,108,162 g/kg-dosage have good development in 30-day feeding test.No o... |
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| Keywords: | transgenic Cucumis melo WMV-2CP gene toxicity experiment mutation experiment feeding test |
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