| 氧化法合成非索非那定吡啶盐及其机理研究 |
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| 引用本文： | 李小玲,沈超,郑辉,章鹏飞. 氧化法合成非索非那定吡啶盐及其机理研究[J]. 杭州师范大学学报(自然科学版), 2011, 0(5): 416-421 |
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| 作者姓名： | 李小玲 沈超 郑辉 章鹏飞 |
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| 作者单位： | 杭州师范大学材料与化学化工学院;杭州广林生物医药有限公司; |
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| 基金项目： | National Natural Science Foundation of China(21076052) |
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| 摘 要： | 报道了一种用简单氧化剂将哌啶衍生物氧化为相应吡啶盐的方法,该方法具有反应条件温和、产率高等优点,并对反应机理进行了研究探讨.
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| 关 键 词： | 吡啶盐 非索非那定 哌啶衍生物 氧化 机理 |
A Novel Synthesis of Fexofenadine Pyridinium Salts by Oxidation of Piperidine Derivatives under Simple Conditions |
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| LI Xiao-ling,,SHEN Chao,ZHENG Hui,ZHANG Peng-fei. A Novel Synthesis of Fexofenadine Pyridinium Salts by Oxidation of Piperidine Derivatives under Simple Conditions[J]. , 2011, 0(5): 416-421 |
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| Authors: | LI Xiao-ling SHEN Chao ZHENG Hui ZHANG Peng-fei |
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| Affiliation: | LI Xiao-ling1,2,SHEN Chao1,ZHENG Hui1,ZHANG Peng-fei1(1.College of Material,Chemistry and Chemical Engineering,Hangzhou Normal University,Hangzhou 310036,China,2.Hangzhou Great Forest Biomedical Ltd.,Hangzhou 310028,China) |
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| Abstract: | The paper reported an efficient synthetic procedure,which has mild response conditions and high productivity,for the preparation of some novel pyridinium salts by oxidation of piperidine derivatives only using some simple oxidants in high yield at ambient temperature and researches on its response mechanisms. |
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| Keywords: | Pyridinium salts fexofenadine piperidine derivatives oxidation mechanism |
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